Chasing his 18th Grand Slam singles title, world number one Djokovic was in total control against his 28th-seeded opponent, winning 6-3, 6-3, 6-1 in one hour and 42 minutes to progress to the last 16 in the men's singles.
In just the third minute of the first half, 17-year-old Fati drew a foul from Serhiy Kyrvstov to earn a penalty that Sergio Ramos converted clinically.
Liang Weikeng/Zheng Xuhui moved past Dong Weijie/Ni Bowen in the mixed doubles to overtake the lead for Shenzhen, while Han Qianxi overwhelmed Zhang Yiman in the women's singles to level for Zhejiang.
Llorente and Joao Tomas will give hope for another top-three finish, but with no new faces so far this summer, there is no reason to think that Atletico will mount a serious title campaign.
The result at Morumbi stadium marked Sao Paulo's fourth victory in five matches and lifted the Tricolor to second, a point behind Internacional.
"Holding the Expo in the Olympic city of Beijing sends a strong signal of confidence. The world of sport is ready to contribute to the recovery from the crisis and to rebuilding a more human-centered and inclusive society."
Hazard could be Madrid's 'signing' of the summer. The winger arrived unfit 12 months ago and struggled with injuries all season, but anyone who has seen him play for Chelsea knows what Hazard can do, and if the Belgian returns to his best he will add another dimension to Madrid's front line in terms of movement, dribbles, assists and goals.
"It was a very good performance from my side. I managed to read his serve well," Djokovic said. "I found my way, especially after the first set. The second and third sets were a really great feeling on the court."
"In accordance with the Grand Slam rulebook, following his actions of intentionally hitting a ball dangerously or recklessly within the court or hitting a ball with negligent disregard of the consequences, the US Open tournament referee defaulted Novak Djokovic from the 2020 US Open," organizers said in a statement.
Rodriguinho had given Bahia the lead at Internacional's Beira-Rio stadium when he cut onto his left foot and slotted a low shot into the bottom left corner.
In the final clash of the mixed doubles, Feng Yanzhe/Lin Lingfang, the gold medalists at the 2019 World Youth Championships, controlled the game to sweep Ye Yuanpeng/Yang Xiaole 11-2, 11-3, 11-4, securing the victory for Ruichang.